血液腫瘍病理学

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Neoplastic Hematopathology: WHO 2016にそった分類による †

造血細胞分化 Human hematopoiesis

Myeloid neoplasms and acute leukemia †

Myeloproliferative neoplasms †

• JAK/STATシグナリング

• Chronic myeloid leukemia (CML), BCR-ABL1+

• Chronic neutrophilic leukemia (CNL)

• Polycythemia vera (PV)

• Primary myelofibrosis (PMF)

• PMF, prefibrotic/early stage--->Meet the Expert2019 case study

• PMF, overt fibrotic stage

• Essential thrombocythemia (ET)-->本態性血小板血症, MPL遺伝子とtriple-negative ET, MPNsの遺伝子変異；canonical gene mutations

• Chronic eosinophilic leukaemia, not otherwise specified--->eosinophiliaが著明な骨髄増殖性腫瘍

• MPN, unclassifiable

• MPNの病理--->100例のMPN症例スライドをみる会---第10回東京骨髄病理研究会

• MPNの病理02--->[[Meet the Expert: MPNの病理診断, 症例研究]]

Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1 †

• Myeloid/lymphoid neoplasms with PDGFRA rearrangement---疾患解説と症例のページあり.

• Myeloid/lymphoid neoplasms with PDGFRB rearrangement

• Myeloid/lymphoid neoplasms with FGFR1 rearrangement

• Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK2

Myelodysplastic/ Myeloproliferative neoplasms †

• Chronic myelomonocytic leukaemia (CMML)

• Atypical chronic myeloid leukemia (aCML), BCR-ABL-

• Juvenile myelomonocytic leukemia (JMML)---疾患解説ページ

• MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)

• MDS/MPN, unclassifiable

Myelodysplastic syndromes †

• 骨髄異形成症候群 Myelodysplastic syndrome(MDS)WHO 4thEd分類

• MDS up-to date; 第２回東日本骨髄病理研究会講演

• MDSに認められる染色体異常

• MDSの遺伝子異常-エピジェネティック制御因子をコードする遺伝子の異常

• MDSの遺伝子異常-pre-mRNAスプライシング機構に関わる遺伝子群の異常

• MDS associated with isolated del(5q):Ribosomal protein S14(RPS14), およびmicroRNAのmiR-145, miR-146a ハプロ不全

• MDS up-to-date: 名古屋第一赤十字病院伊藤雅文先生の講演から
   

• MDS with single lineage dysplasia

• MDS with ring sideroblasts (MDS-RS)

• MDS-RS and single lineage dysplasia

• MDS-RS and multilineage dysplasia

• MDS with multilineage dysplasia

• MDS with excess blasts

• MDS with isolated del(5q)

• MDS, unclassifiable

• Provisional entity: Refractory cytopenia of childhood--->小児MDS

Acute myeloid leukaemia(AML) and related precursor neoplams †

-AML with recurrent genetic abnormalities †

Defined structural abnormalities

• AML with t(8;21)(q22;q22); RUNX1-RUNX1T1

• AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11

• APL with PML-RARA-Acute promyelocytic leukemia with PML-RARA (APL, previously called -AML-M3)

• AML with t(9;11)(p21.3;q23.3); MLLT3-KMT2A

• AML with t(6;9)(p23;q34.1); DEK-NUP214 -AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2,MECOM

• AML (megakaryoblastic) with t(1;22)(p13.3;q13.3); RBM15-MKL1
• AML with BCR-ABL1

AML with gene mutations

• AML with mutated NPM1

• AML with biallelic mutations of CEBPA

• AML with mutated RUNX1

AML WITH MDS-RELATED FEATURES-AML with myelodysplasia-related features (previously called -AML with multilineage dysplasia) †

Therapy-related -AML and MDS †

AML, not otherwise specified †

• AML with minimal differentiation (FAB M0)

• AML without maturation (FAB M1)

• AML with maturation (FAB M2)

• Acute myelomonocytic leukemia (FAB M4)

• Acute monoblastic and monocytic leukemia (FAB M5)

• Pure erythroid leukemia (FAB M6)

• Acute megakaryoblastic leukemia (FAB M7)

• Acute basophilic leukemia

• Acute panmyelosis with myelofibrosis

MYELOID SARCOMA　 †

MYELOID PROLIFERATIONS RELATED TO DOWN SYNDROME †

• Transient myeloproliferative disorder (TMD, also called transient abnormal myelopoiesis).

• AML of Down syndrome (DS--AML)

Blastic plasmacytoid dendritic cell neoplasm †

• MLL Mixed-Lineage Leukemia Gene

• FLT3 mutationをもつ Leukemia

Acute luekaemia with ambiguous lineage †

Acute leukemias of ambiguous lineage include the following

• Acute undifferentiated acute leukemia

• Mixed phenotype acute leukemia with t(9;22)(q34;q112.); BCR-ABL1

• Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged

• Mixed phenotype acute leukemia, B/myeloid, NOS

• Mixed phenotype acute leukemia, T/myeloid, NOS

• Mixed phenotype acute leukemia, NOS rare types

• Other acute leukemias of -AMbiguous lineage

lymphoid neoplasms WHO2016 †

最新のWHO分類; Swerdlow SH, Campo E, Harris N, et al.(eds.): WHO classification of Tumours of Haematopoietic and Lymphoid Tissues, revied 4th ed., IARC Press, Lyon, 2017

Precursor lymphoid neoplasmas †

Mature B-cell neoplasms †

• Chronic lymphocytic leukemia/small lymphocytic lymphoma

• Monoclonal B-cell lymphocytosis*

• B-cell prolymphocytic leukemia

• Splenic marginal zone lymphoma

• Hairy cell leukemia

• Splenic B-cell lymphoma/leukemia, unclassifiable

• Splenic diffuse red pulp small B-cell lymphoma

• Hairy cell leukemia-variant

• Lymphoplasmacytic lymphoma

• Waldenstrom macroglobulinemia

• Monoclonal gammopathy of undetermined significance (MGUS), IgM*

• μ heavy-chain disease

• γ heavy-chain disease

• α heavy-chain disease

• Monoclonal gammopathy of undetermined significance (MGUS), IgG/A*

• Plasma cell myeloma

• Solitary plasmacytoma of bone

• Extraosseous plasmacytoma

• Monoclonal immunoglobulin deposition diseases*

• Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)

• Nodal marginal zone lymphoma

• Pediatric nodal marginal zone lymphoma

• Follicular lymphoma

• In situ follicular neoplasia*

• Duodenal-type follicular lymphoma*

• Pediatric-type follicular lymphoma*

• Large B-cell lymphoma with IRF4 rearrangement*

• Primary cutaneous follicle center lymphoma

• Mantle cell lymphoma

• In situ mantle cell neoplasia*

• Diffuse large B-cell lymphoma (DLBCL), NOS

• Germinal center B-cell type*

• Activated B-cell type*

• T-cell/histiocyte-rich large B-cell lymphoma

• Primary DLBCL of the central nervous system (CNS)

• Primary cutaneous DLBCL, leg type

• EBV+ DLBCL, NOS*

• EBV+ mucocutaneous ulcer*

• DLBCL associated with chronic inflammation

• Lymphomatoid granulomatosis

• Primary mediastinal (thymic) large B-cell lymphoma

• Intravascular large B-cell lymphoma

• ALK+ large B-cell lymphoma (WHO2008,2016)

• Plasmablastic lymphoma

• Primary effusion lymphoma

• HHV8+ DLBCL, NOS*

• Burkitt lymphoma

• Burkitt-like lymphoma with 11q aberration*

• High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements*

• High-grade B-cell lymphoma, NOS*

• B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

Mature T- and NK-cell neoplasms †

• T-cell prolymphocytic leukemia

• T-cell large granular lymphocytic leukemia>

• Chronic lymphoproliferative disorder of NK cells

• Aggressive NK-cell leukemia

• Systemic EBV+ T-cell lymphoma of childhood*

• Hydroa vacciniforme-like lymphoproliferative disorder*

• Adult T-cell leukemia/lymphoma

• Extranodal Natural Killer(NK)/T-Cell Lymphoma, Nasal Type

• Enteropathy-associated T-cell lymphoma

• Monomorphic epitheliotropic intestinal T-cell lymphoma*

• Indolent T-cell lymphoproliferative disorder of the GI tract*

• Hepatosplenic T-cell lymphoma

• Subcutaneous panniculitis-like T-cell lymphoma

• Mycosis fungoides

• Sezary syndrome

• Primary cutaneous CD30+ T-cell lymphoproliferative disorders

• Lymphomatoid papulosis

• Primary cutaneous anaplastic large cell lymphoma

• Primary cutaneous γδ T-cell lymphoma

• Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma

• Primary cutaneous acral CD8+ T-cell lymphoma*

• Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder*

• Peripheral T-cell lymphoma, NOS

• Angioimmunoblastic T-cell lymphoma

• Follicular T-cell lymphoma*

• Nodal peripheral T-cell lymphoma with TFH phenotype*

• Anaplastic large-cell lymphoma, ALK+

• Anaplastic large-cell lymphoma, ALK-*

• Breast implant-associated anaplastic large-cell lymphoma*

Hodgkin lymphoma †

Hodgkin lymphoma

• Nodular lymphocyte predominant Hodgkin lymphoma

• Classical Hodgkin lymphoma

• Nodular sclerosis classical Hodgkin lymphoma

• Lymphocyte-rich classical Hodgkin lymphoma

• Mixed cellularity classical Hodgkin lymphoma

• Lymphocyte-depleted classical Hodgkin lymphoma: (ALK+) anaplastic large cell lymphomaが多くふくまれていたと考えられる.

Posttransplant lymphoproliferative disorders (PTLD) WHO2016 †

• Plasmacytic hyperplasia PTLD

• Infectious mononucleosis PTLD

• Florid follicular hyperplasia PTLD*

• Polymorphic PTLD

• Monomorphic PTLD (B- and T-/NK-cell types)

• Classical Hodgkin lymphoma PTLD

Histiocytic and dendritic cell neoplasms †

• Histiocytic sarcoma

• Langerhans cell histiocytosis

• Langerhans cell sarcoma--->Langerhans cell sarcoma-231SPS-Case03

• Indeterminate dendritic cell tumor

• Interdigitating dendritic cell sarcoma

• Follicular dendritic cell sarcoma

• Fibroblastic reticular cell tumor

• Disseminated juvenile xanthogranuloma

• Erdheim-Chester disease*

血液腫瘍病理学のお勉強 †

• Aplastic anemia (AA)

日本病理学会 †

日本血液病理研究会 †

日本網内系学会 †

リンパ腫スキルアップセミナー †

日本病理学会中部支部交見会血液関連症例 †

日本病理学会中部支部スライドセミナ血液関連セミナ †

日本血液学会 †

日本血液学会公式ホームページ クリックで移動

東京骨髄病理研究会 †

東京骨髄病理研究会の管理人まとめページ

第6回東京骨髄病理研究会

第5回東京骨髄病理研究会

第4回東京骨髄病理研究会

第3回東京骨髄病理研究会

第２回東京骨髄病理研究会

第１回東京骨髄病理研究会

関東リンパ腫診断研究会(リンフォマニアの会) †

リンフォマニアになるためのリンパ腫病理診断コース

東海大学公式のリンフォマニアになるためのリンパ腫病理診断コースホームページ クリックで移動

Mature B-cell neoplasms

• Chronic lymphocytic leukemia/small lymphocytic lymphoma

• Monoclonal B-cell lymphocytosis*

• B-cell prolymphocytic leukemia

• Splenic marginal zone lymphoma

• Hairy cell leukemia

• Splenic B-cell lymphoma/leukemia, unclassifiable

• Splenic diffuse red pulp small B-cell lymphoma

• Hairy cell leukemia-variant

• Lymphoplasmacytic lymphoma

• Waldenstrom macroglobulinemia

• Monoclonal gammopathy of undetermined significance (MGUS), IgM*

• μ heavy-chain disease

• γ heavy-chain disease

• α heavy-chain disease

• Monoclonal gammopathy of undetermined significance (MGUS), IgG/A*

• Plasma cell myeloma

• Solitary plasmacytoma of bone

• Extraosseous plasmacytoma

• Monoclonal immunoglobulin deposition diseases*

• Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)

• Nodal marginal zone lymphoma

• Pediatric nodal marginal zone lymphoma

• Follicular lymphoma

• In situ follicular neoplasia*

• Duodenal-type follicular lymphoma*

• Pediatric-type follicular lymphoma*

• Large B-cell lymphoma with IRF4 rearrangement*

• Primary cutaneous follicle center lymphoma

• Mantle cell lymphoma

• In situ mantle cell neoplasia*

• Diffuse large B-cell lymphoma (DLBCL), NOS

• Germinal center B-cell type*

• Activated B-cell type*

• T-cell/histiocyte-rich large B-cell lymphoma

• Primary DLBCL of the central nervous system (CNS)

• Primary cutaneous DLBCL, leg type

• EBV+ DLBCL, NOS*

• EBV+ mucocutaneous ulcer*

• DLBCL associated with chronic inflammation

• Lymphomatoid granulomatosis

• Primary mediastinal (thymic) large B-cell lymphoma

• Intravascular large B-cell lymphoma

• ALK+ large B-cell lymphoma

• Plasmablastic lymphoma

• Primary effusion lymphoma

• HHV8+ DLBCL, NOS*

• Burkitt lymphoma

• Burkitt-like lymphoma with 11q aberration*

• High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements*

• High-grade B-cell lymphoma, NOS*

• B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

Mature T and NK neoplasms

• T-cell prolymphocytic leukemia

• T-cell large granular lymphocytic leukemia>

• Chronic lymphoproliferative disorder of NK cells
• Aggressive NK-cell leukemia
• Systemic EBV+ T-cell lymphoma of childhood*
• Hydroa vacciniforme-like lymphoproliferative disorder*
• Adult T-cell leukemia/lymphoma
• Extranodal Natural Killer(NK)/T-Cell Lymphoma, Nasal Type
• Enteropathy-associated T-cell lymphoma
• Monomorphic epitheliotropic intestinal T-cell lymphoma*
• Indolent T-cell lymphoproliferative disorder of the GI tract*
• Hepatosplenic T-cell lymphoma
• Subcutaneous panniculitis-like T-cell lymphoma
• Mycosis fungoides
• Sezary syndrome
• Primary cutaneous CD30+ T-cell lymphoproliferative disorders
  • Lymphomatoid papulosis
  • Primary cutaneous anaplastic large cell lymphoma
• Primary cutaneous γδ T-cell lymphoma
• Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
• Primary cutaneous acral CD8+ T-cell lymphoma*
• Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder*
• Peripheral T-cell lymphoma, NOS
• Angioimmunoblastic T-cell lymphoma
• Follicular T-cell lymphoma*
• Nodal peripheral T-cell lymphoma with TFH phenotype*
• Anaplastic large-cell lymphoma, ALK+
• Anaplastic large-cell lymphoma, ALK-*
• Breast implant-associated anaplastic large-cell lymphoma* Hodgkin lymphoma
• Nodular lymphocyte predominant Hodgkin lymphoma
• Classical Hodgkin lymphoma
  • Nodular sclerosis classical Hodgkin lymphoma
  • Lymphocyte-rich classical Hodgkin lymphoma
  • Mixed cellularity classical Hodgkin lymphoma
  • Lymphocyte-depleted classical Hodgkin lymphoma Posttransplant lymphoproliferative disorders (PTLD)
• Plasmacytic hyperplasia PTLD
• Infectious mononucleosis PTLD
• Florid follicular hyperplasia PTLD*
• Polymorphic PTLD
• Monomorphic PTLD (B- and T-/NK-cell types)
• Classical Hodgkin lymphoma PTLD Histiocytic and dendritic cell neoplasms
• Histiocytic sarcoma
• Langerhans cell histiocytosis
• Langerhans cell sarcoma
• Indeterminate dendritic cell tumor
• Interdigitating dendritic cell sarcoma
• Follicular dendritic cell sarcoma
• Fibroblastic reticular cell tumor
• Disseminated juvenile xanthogranuloma
• Erdheim-Chester disease*

Lymphomatoid granulomatosis SPS218-Case01

Myeloproliferative neoplasms (MPN)

• Chronic myeloid leukemia (CML), BCR-ABL1+

• Chronic neutrophilic leukemia (CNL)

• Polycythemia vera (PV)

• Primary myelofibrosis (PMF)

• PMF, prefibrotic/early stage

• PMF, overt fibrotic stage

• Essential thrombocythemia (ET)

• Chronic eosinophilic leukemia, not otherwise specified (NOS)

• MPN, unclassifiable

Mastocytosis

Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2

• Myeloid/lymphoid neoplasms with PDGFRA rearrangement

• Myeloid/lymphoid neoplasms with PDGFRB rearrangement

• Myeloid/lymphoid neoplasms with FGFR1 rearrangement

• Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK2

Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)

• Chronic myelomonocytic leukemia (CMML)

• Atypical chronic myeloid leukemia (aCML), BCR-ABL1-

• Juvenile myelomonocytic leukemia (JMML)

• MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)

• MDS/MPN, unclassifiable

Myelodysplastic syndromes (MDS)

• MDS with single lineage dysplasia

• MDS with ring sideroblasts (MDS-RS)

• MDS-RS and single lineage dysplasia

• MDS-RS and multilineage dysplasia

• MDS with multilineage dysplasia

• MDS with excess blasts

• MDS with isolated del(5q)

• MDS, unclassifiable

• Provisional entity: Refractory cytopenia of childhood

Myeloid neoplasms with germ line predisposition

Acute myeloid leukemia (AML) and related neoplasms

• AML with recurrent genetic abnormalities

• AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1

• AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFB-MYH11

• APL with PML-RARA

• AML with t(9;11)(p21.3;q23.3);MLLT3-KMT2A

• AML with t(6;9)(p23;q34.1);DEK-NUP214

• AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM

• AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1

• Provisional entity: AML with BCR-ABL1

• AML with mutated NPM1

• AML with biallelic mutations of CEBPA

• Provisional entity: AML with mutated RUNX1

• AML with myelodysplasia-related changes

• Therapy-related myeloid neoplasms

• AML, NOS

• AML with minimal differentiation

• AML without maturation

• AML with maturation

• Acute myelomonocytic leukemia

• Acute monoblastic/monocytic leukemia

• Pure erythroid leukemia

• Acute megakaryoblastic leukemia

• Acute basophilic leukemia

• Acute panmyelosis with myelofibrosis

• Myeloid sarcoma

• Myeloid proliferations related to Down syndrome

• Transient abnormal myelopoiesis (TAM)

• Myeloid leukemia associated with Down syndrome

Blastic plasmacytoid dendritic cell neoplasm

Acute leukemias of ambiguous lineage

• Acute undifferentiated leukemia

• Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34.1;q11.2); BCR-ABL1

• MPAL with t(v;11q23.3); KMT2A rearranged

• MPAL, B/myeloid, NOS

• MPAL, T/myeloid, NOS

B-lymphoblastic leukemia/lymphoma

• B-lymphoblastic leukemia/lymphoma, NOS

• B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities

• B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2);BCR-ABL1

• B-lymphoblastic leukemia/lymphoma with t(v;11q23.3);KMT2A rearranged

• B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

• B-lymphoblastic leukemia/lymphoma with hyperdiploidy

• B-lymphoblastic leukemia/lymphoma with hypodiploidy

• B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3) IL3-IGH

• B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1

• Provisional entity: B-lymphoblastic leukemia/lymphoma, BCR-ABL1-like

• Provisional entity: B-lymphoblastic leukemia/lymphoma with iAMP21

T-lymphoblastic leukemia/lymphoma

• Provisional entity: Early T-cell precursor lymphoblastic leukemia

Provisional entity: Natural killer (NK) cell lymphoblastic leukemia/lymphoma