WikiPathologica
Neoplastic Hematopathology: WHO 2016にそった分類による †
造血細胞分化 Human hematopoiesis
Myeloid neoplasms and acute leukemia †
Myeloproliferative neoplasms †
- Chronic myeloid leukemia (CML), BCR-ABL1+
- Primary myelofibrosis (PMF)
- PMF, prefibrotic/early stage--->Meet the Expert2019 case study
- MPNの病理02--->[[Meet the Expert: MPNの病理診断, 症例研究]]
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1 †
- Myeloid/lymphoid neoplasms with PDGFRB rearrangement
- Myeloid/lymphoid neoplasms with FGFR1 rearrangement
- Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK2
Myelodysplastic/ Myeloproliferative neoplasms †
- MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)
Myelodysplastic syndromes †
- 骨髄異形成症候群 Myelodysplastic syndrome(MDS)WHO 4thEd分類
- MDS up-to date; 第2回東日本骨髄病理研究会講演
- MDS with single lineage dysplasia
- MDS with ring sideroblasts (MDS-RS)
- MDS-RS and single lineage dysplasia
- MDS-RS and multilineage dysplasia
- MDS with multilineage dysplasia
- Provisional entity: Refractory cytopenia of childhood--->小児MDS
Acute myeloid leukaemia(AML) and related precursor neoplams †
-AML with recurrent genetic abnormalities †
Defined structural abnormalities
- AML with t(8;21)(q22;q22); RUNX1-RUNX1T1
- AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
- AML with t(9;11)(p21.3;q23.3); MLLT3-KMT2A
- AML with t(6;9)(p23;q34.1); DEK-NUP214 -AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2,MECOM
- AML (megakaryoblastic) with t(1;22)(p13.3;q13.3); RBM15-MKL1
- AML with BCR-ABL1
AML with gene mutations
- AML with biallelic mutations of CEBPA
AML WITH MDS-RELATED FEATURES-AML with myelodysplasia-related features (previously called -AML with multilineage dysplasia) †
Therapy-related -AML and MDS †
AML, not otherwise specified †
- AML with minimal differentiation (FAB M0)
- AML without maturation (FAB M1)
- AML with maturation (FAB M2)
- Acute myelomonocytic leukemia (FAB M4)
- Acute monoblastic and monocytic leukemia (FAB M5)
- Pure erythroid leukemia (FAB M6)
- Acute basophilic leukemia
- Acute panmyelosis with myelofibrosis
MYELOID SARCOMA †
MYELOID PROLIFERATIONS RELATED TO DOWN SYNDROME †
- Transient myeloproliferative disorder (TMD, also called transient abnormal myelopoiesis).
- AML of Down syndrome (DS--AML)
Blastic plasmacytoid dendritic cell neoplasm †
- MLL Mixed-Lineage Leukemia Gene
Acute luekaemia with ambiguous lineage †
Acute leukemias of ambiguous lineage include the following
- Acute undifferentiated acute leukemia
- Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged
- Mixed phenotype acute leukemia, B/myeloid, NOS
- Mixed phenotype acute leukemia, T/myeloid, NOS
- Mixed phenotype acute leukemia, NOS rare types
- Other acute leukemias of -AMbiguous lineage
lymphoid neoplasms WHO2016 †
最新のWHO分類; Swerdlow SH, Campo E, Harris N, et al.(eds.): WHO classification of Tumours of Haematopoietic and Lymphoid Tissues, revied 4th ed., IARC Press, Lyon, 2017
Precursor lymphoid neoplasmas †
Mature B-cell neoplasms †
- Monoclonal B-cell lymphocytosis*
- B-cell prolymphocytic leukemia
- Splenic marginal zone lymphoma
- Splenic B-cell lymphoma/leukemia, unclassifiable
- Splenic diffuse red pulp small B-cell lymphoma
- Hairy cell leukemia-variant
- Monoclonal gammopathy of undetermined significance (MGUS), IgM*
- Monoclonal gammopathy of undetermined significance (MGUS), IgG/A*
- Solitary plasmacytoma of bone
- Extraosseous plasmacytoma
- Monoclonal immunoglobulin deposition diseases*
- Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
- Nodal marginal zone lymphoma
- Pediatric nodal marginal zone lymphoma
- In situ follicular neoplasia*
- Duodenal-type follicular lymphoma*
- Pediatric-type follicular lymphoma*
- Large B-cell lymphoma with IRF4 rearrangement*
- Primary cutaneous follicle center lymphoma
- In situ mantle cell neoplasia*
- Germinal center B-cell type*
- T-cell/histiocyte-rich large B-cell lymphoma
- Primary DLBCL of the central nervous system (CNS)
- Primary cutaneous DLBCL, leg type
- EBV+ mucocutaneous ulcer*
- DLBCL associated with chronic inflammation
- Primary mediastinal (thymic) large B-cell lymphoma
- Intravascular large B-cell lymphoma
- Primary effusion lymphoma
- Burkitt-like lymphoma with 11q aberration*
- High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements*
- High-grade B-cell lymphoma, NOS*
- B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
Mature T- and NK-cell neoplasms †
- T-cell prolymphocytic leukemia
- Chronic lymphoproliferative disorder of NK cells
- Aggressive NK-cell leukemia
- Systemic EBV+ T-cell lymphoma of childhood*
- Hydroa vacciniforme-like lymphoproliferative disorder*
- Enteropathy-associated T-cell lymphoma
- Monomorphic epitheliotropic intestinal T-cell lymphoma*
- Indolent T-cell lymphoproliferative disorder of the GI tract*
- Primary cutaneous CD30+ T-cell lymphoproliferative disorders
- Primary cutaneous anaplastic large cell lymphoma
- Primary cutaneous γδ T-cell lymphoma
- Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
- Primary cutaneous acral CD8+ T-cell lymphoma*
- Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder*
- Angioimmunoblastic T-cell lymphoma
- Follicular T-cell lymphoma*
- Nodal peripheral T-cell lymphoma with TFH phenotype*
- Anaplastic large-cell lymphoma, ALK-*
- Breast implant-associated anaplastic large-cell lymphoma*
Hodgkin lymphoma †
Hodgkin lymphoma
- Nodular lymphocyte predominant Hodgkin lymphoma
- Classical Hodgkin lymphoma
- Nodular sclerosis classical Hodgkin lymphoma
- Lymphocyte-rich classical Hodgkin lymphoma
- Mixed cellularity classical Hodgkin lymphoma
- Lymphocyte-depleted classical Hodgkin lymphoma
Posttransplant lymphoproliferative disorders (PTLD) WHO2016 †
- Plasmacytic hyperplasia PTLD
- Infectious mononucleosis PTLD
- Florid follicular hyperplasia PTLD*
- Monomorphic PTLD (B- and T-/NK-cell types)
- Classical Hodgkin lymphoma PTLD
Histiocytic and dendritic cell neoplasms †
- Langerhans cell histiocytosis
- Indeterminate dendritic cell tumor
- Interdigitating dendritic cell sarcoma
- Follicular dendritic cell sarcoma
- Fibroblastic reticular cell tumor
- Disseminated juvenile xanthogranuloma
血液腫瘍病理学のお勉強 †
日本病理学会 †
日本血液病理研究会 †
日本網内系学会 †
リンパ腫スキルアップセミナー †
日本病理学会中部支部交見会血液関連症例 †
日本病理学会中部支部スライドセミナ血液関連セミナ †
日本血液学会 †
日本血液学会公式ホームページ クリックで移動
東京骨髄病理研究会 †
東京骨髄病理研究会の管理人まとめページ
第6回東京骨髄病理研究会
第5回東京骨髄病理研究会
第4回東京骨髄病理研究会
第3回東京骨髄病理研究会
第2回東京骨髄病理研究会
第1回東京骨髄病理研究会
関東リンパ腫診断研究会(リンフォマニアの会) †
リンフォマニアになるためのリンパ腫病理診断コース
東海大学公式のリンフォマニアになるためのリンパ腫病理診断コースホームページ クリックで移動
Mature B-cell neoplasms
- Chronic lymphocytic leukemia/small lymphocytic lymphoma
- Monoclonal B-cell lymphocytosis*
- B-cell prolymphocytic leukemia
- Splenic marginal zone lymphoma
- Splenic B-cell lymphoma/leukemia, unclassifiable
- Splenic diffuse red pulp small B-cell lymphoma
- Hairy cell leukemia-variant
- Lymphoplasmacytic lymphoma
- Waldenstrom macroglobulinemia
- Monoclonal gammopathy of undetermined significance (MGUS), IgM*
- Monoclonal gammopathy of undetermined significance (MGUS), IgG/A*
- Solitary plasmacytoma of bone
- Extraosseous plasmacytoma
- Monoclonal immunoglobulin deposition diseases*
- Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
- Nodal marginal zone lymphoma
- Pediatric nodal marginal zone lymphoma
- In situ follicular neoplasia*
- Duodenal-type follicular lymphoma*
- Pediatric-type follicular lymphoma*
- Large B-cell lymphoma with IRF4 rearrangement*
- Primary cutaneous follicle center lymphoma
- In situ mantle cell neoplasia*
- Diffuse large B-cell lymphoma (DLBCL), NOS
- Germinal center B-cell type*
- T-cell/histiocyte-rich large B-cell lymphoma
- Primary DLBCL of the central nervous system (CNS)
- Primary cutaneous DLBCL, leg type
- EBV+ mucocutaneous ulcer*
- DLBCL associated with chronic inflammation
- Lymphomatoid granulomatosis
- Primary mediastinal (thymic) large B-cell lymphoma
- Intravascular large B-cell lymphoma
- ALK+ large B-cell lymphoma
- Primary effusion lymphoma
- Burkitt-like lymphoma with 11q aberration*
- High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements*
- High-grade B-cell lymphoma, NOS*
- B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
Mature T and NK neoplasms
- T-cell prolymphocytic leukemia
- Chronic lymphoproliferative disorder of NK cells
- Aggressive NK-cell leukemia
- Systemic EBV+ T-cell lymphoma of childhood*
- Hydroa vacciniforme-like lymphoproliferative disorder*
- Adult T-cell leukemia/lymphoma
- Extranodal Natural Killer(NK)/T-Cell Lymphoma, Nasal Type
- Enteropathy-associated T-cell lymphoma
- Monomorphic epitheliotropic intestinal T-cell lymphoma*
- Indolent T-cell lymphoproliferative disorder of the GI tract*
- Hepatosplenic T-cell lymphoma
- Subcutaneous panniculitis-like T-cell lymphoma
- Mycosis fungoides
- Sezary syndrome
- Primary cutaneous CD30+ T-cell lymphoproliferative disorders
- Lymphomatoid papulosis
- Primary cutaneous anaplastic large cell lymphoma
- Primary cutaneous γδ T-cell lymphoma
- Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
- Primary cutaneous acral CD8+ T-cell lymphoma*
- Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder*
- Peripheral T-cell lymphoma, NOS
- Angioimmunoblastic T-cell lymphoma
- Follicular T-cell lymphoma*
- Nodal peripheral T-cell lymphoma with TFH phenotype*
- Anaplastic large-cell lymphoma, ALK+
- Anaplastic large-cell lymphoma, ALK-*
- Breast implant-associated anaplastic large-cell lymphoma*
Hodgkin lymphoma
- Nodular lymphocyte predominant Hodgkin lymphoma
- Classical Hodgkin lymphoma
- Nodular sclerosis classical Hodgkin lymphoma
- Lymphocyte-rich classical Hodgkin lymphoma
- Mixed cellularity classical Hodgkin lymphoma
- Lymphocyte-depleted classical Hodgkin lymphoma
Posttransplant lymphoproliferative disorders (PTLD)
- Plasmacytic hyperplasia PTLD
- Infectious mononucleosis PTLD
- Florid follicular hyperplasia PTLD*
- Polymorphic PTLD
- Monomorphic PTLD (B- and T-/NK-cell types)
- Classical Hodgkin lymphoma PTLD
Histiocytic and dendritic cell neoplasms
- Histiocytic sarcoma
- Langerhans cell histiocytosis
- Langerhans cell sarcoma
- Indeterminate dendritic cell tumor
- Interdigitating dendritic cell sarcoma
- Follicular dendritic cell sarcoma
- Fibroblastic reticular cell tumor
- Disseminated juvenile xanthogranuloma
- Erdheim-Chester disease*
Lymphomatoid granulomatosis SPS218-Case01
Myeloproliferative neoplasms (MPN)
- Chronic myeloid leukemia (CML), BCR-ABL1+
- Chronic neutrophilic leukemia (CNL)
- Primary myelofibrosis (PMF)
- PMF, prefibrotic/early stage
- PMF, overt fibrotic stage
- Essential thrombocythemia (ET)
- Chronic eosinophilic leukemia, not otherwise specified (NOS)
Mastocytosis
Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2
- Myeloid/lymphoid neoplasms with PDGFRA rearrangement
- Myeloid/lymphoid neoplasms with PDGFRB rearrangement
- Myeloid/lymphoid neoplasms with FGFR1 rearrangement
- Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK2
Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)
- Chronic myelomonocytic leukemia (CMML)
- Atypical chronic myeloid leukemia (aCML), BCR-ABL1-
- Juvenile myelomonocytic leukemia (JMML)
- MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)
Myelodysplastic syndromes (MDS)
- MDS with single lineage dysplasia
- MDS with ring sideroblasts (MDS-RS)
- MDS-RS and single lineage dysplasia
- MDS-RS and multilineage dysplasia
- MDS with multilineage dysplasia
- MDS with isolated del(5q)
- Provisional entity: Refractory cytopenia of childhood
Myeloid neoplasms with germ line predisposition
Acute myeloid leukemia (AML) and related neoplasms
- AML with recurrent genetic abnormalities
- AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1
- AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFB-MYH11
- AML with t(9;11)(p21.3;q23.3);MLLT3-KMT2A
- AML with t(6;9)(p23;q34.1);DEK-NUP214
- AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM
- AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1
- Provisional entity: AML with BCR-ABL1
- AML with biallelic mutations of CEBPA
- Provisional entity: AML with mutated RUNX1
- AML with myelodysplasia-related changes
- Therapy-related myeloid neoplasms
- AML with minimal differentiation
- Acute myelomonocytic leukemia
- Acute monoblastic/monocytic leukemia
- Acute megakaryoblastic leukemia
- Acute basophilic leukemia
- Acute panmyelosis with myelofibrosis
- Myeloid proliferations related to Down syndrome
- Transient abnormal myelopoiesis (TAM)
- Myeloid leukemia associated with Down syndrome
Blastic plasmacytoid dendritic cell neoplasm
Acute leukemias of ambiguous lineage
- Acute undifferentiated leukemia
- Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34.1;q11.2); BCR-ABL1
- MPAL with t(v;11q23.3); KMT2A rearranged
B-lymphoblastic leukemia/lymphoma
- B-lymphoblastic leukemia/lymphoma, NOS
- B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
- B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2);BCR-ABL1
- B-lymphoblastic leukemia/lymphoma with t(v;11q23.3);KMT2A rearranged
- B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1
- B-lymphoblastic leukemia/lymphoma with hyperdiploidy
- B-lymphoblastic leukemia/lymphoma with hypodiploidy
- B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3) IL3-IGH
- B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1
- Provisional entity: B-lymphoblastic leukemia/lymphoma, BCR-ABL1-like
- Provisional entity: B-lymphoblastic leukemia/lymphoma with iAMP21
T-lymphoblastic leukemia/lymphoma
- Provisional entity: Early T-cell precursor lymphoblastic leukemia
Provisional entity: Natural killer (NK) cell lymphoblastic leukemia/lymphoma
|